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The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location

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No 2023–2026 peer-reviewed musculoskeletal study explicitly labelled "TB-500" appears in PubMed, and ongoing soft-tissue and ocular-surface work continues to use full-length Tβ4 [5][7]